Review of thepathogenesis of chronic uric acid nephropathy
10.3969/j.issn.1006-6187.2016.07.020
- VernacularTitle:慢性尿酸性肾病发病机制研究现状
- Author:
Kaisi ZHU
1
;
Caixiang ZHANG
Author Information
1. 中国人民解放军第305医院内分泌科
- Keywords:
Hyperuricemia;
Kidney injury;
Renal fibrosis
- From:
Chinese Journal of Diabetes
2017;25(10):950-952
- CountryChina
- Language:Chinese
-
Abstract:
Hyperuricemia is the result of purine metabolic or excretion disorder.Continuous hyperuricemia can cause chronic uric acid nephropathy (gouty nephropathy),which will induce varying degrees of renal disfunction and impair life.Uric acid contributes to kidney injury by inducing inflammation,endothelial dysfunction,oxidative stress,and activation of the renin-angiotensin system(RAS),and cause chronic uric acid nephropathy.Thorough tnderstanding of.the pathogenesis of chronic uric acid nephropathy is beneficial for dru development and evaluating disease prognosis.Here,we reviewed of the pathogenesis of chronic uric acid nephropathy.
