Updates on the relationship between PAPP-A2 and fetus disease
10.3760/cma.j.issn.1673-4408.2017.10.008
- VernacularTitle:PAPP-A2基因与胎儿疾病相关性研究进展
- Author:
Yufan CHEN
1
Author Information
1. 中国医科大学附属盛京医院小儿骨科
- Keywords:
PAPP-A2;
Pre-eclampsia;
Developmental dysplasia of the hip
- From:
International Journal of Pediatrics
2017;44(10):686-688,696
- CountryChina
- Language:Chinese
-
Abstract:
Pregnancy-associated plasma protein-A2(PAPP-A2)is a metalloproteinase,which expresses in many tissues and cells,especially in maternal serum and placenta.PAPP-A2 plays an important role in the em-bryonic growth and development. Abnormal PAPP-A2 levels are associated with pre-eclampsia,Down's syn-drome,developmental dysplasia of the hip and other diseases,but the specific mechanism is still unclear.The mo-lecular structure and function of PAPP-A2,the research advances in the relationship between PAPP-A2 and fetus disease are reviewed in this paper.
