Advances in the research on application and antitumor mechanism of snake venom
10.3969/j.issn.1000-8179.2017.19.143
- VernacularTitle:蛇毒抗肿瘤应用及其机制的研究进展
- Author:
HUANG MIAO
1
Author Information
1. 广西医科大学附属肿瘤医院影像学诊断中心 南宁市530021
- Keywords:
snake venom;
antitumor;
mechanism;
proliferation;
migration;
apoptosis;
angiogenesis
- From:
Chinese Journal of Clinical Oncology
2017;44(19):988-992
- CountryChina
- Language:Chinese
-
Abstract:
Recent literatures on antitumor effect, mechanism, and application of snake venom were summarized. This study aimed to provide a basis for the research, development, and application of snake venom which includes antitumor components. The abilities of snake venom was found in inhibiting tumor proliferation and migration and/or inducing apoptosis in a variety of malignant tumor cells at dose-dependent and/or time-dependent manner. Some types of snake venom inhibit tumoral angiogenesis. Meanwhile, the antitu-mor mechanisms of snake venom were as follows:1) inhibit tumor metastasis by blocking certain signaling pathways, 2) induce apop-tosis of tumor cells by activating the death pathway, 3) inhibit growth and proliferation of tumor cells by regulating the expression of tumor suppressor (promoter) genes or arresting the cell cycle, and 4) inhibit tumoral angiogenesis by inhibiting the expression of VEGF from cancer cells. Thus, snake venom has potential as an antitumor agent.
