Correlation between HLA-DB1 genes and susceptibility to echinococcosis in Tibetan population in Tibetan Plateau
10.16250/j.32.1374.2017075
- VernacularTitle:青藏高原藏族人群HLA-DRB1基因与包虫病遗传抗性关联研究
- Author:
feng Shu GAO
1
;
min Xiu HAN
;
fei Xue ZHANG
;
shun Yong WANG
;
Wei WANG
;
min Ya GUO
;
shou Yong LI
Author Information
1. 青海省人民医院 西宁810000
- Keywords:
Echinococcosis;
HLA-DRB1;
Susceptibility;
Resistance gene;
Association study;
Tibetan Plateau
- From:
Chinese Journal of Schistosomiasis Control
2017;29(5):602-606
- CountryChina
- Language:Chinese
-
Abstract:
Objective To determine the susceptibility genes and resistance genes in HLA-DRB1 alleles in Tibetan patients with cystic and alveolar hydatid diseases,so as to provide the references for the research of the genetic characteristics and infec-tion mechanism of Tibetan hydatid diseases. Methods The case control method was applied. The Tibetan patients with cystic and alveolar hydatid diseases(63 and 73 cases respectively)in Yushu and Guoluo Tibetan Autonomous Prefecture,and unrelat-ed healthy people(60 cases)in this area were selected as the study subjects. The polymerase chain reaction-sequence based typ-ing(PCR-SBT)technique was applied for genotyping of HLA-DRB1,and the comparison of the gene frequency. Results The frequency of HLA-DRB1*04 in the alveolar/cystic echinococcosis group was lower than that in the control group(χ2 =4.71, 4.31,both P<0.05). Conclusion HLA-DRB1*04 genotypes may be associated with the resistance of cystic and alveolar echi-nococcosis and its resistance genes.
