Updates on airway epithelial cells in asthma
10.3760/cma.j.issn.1673-4408.2017.10.004
- VernacularTitle:气道上皮细胞在支气管哮喘发病中的作用
- Author:
Lifeng SUN
1
Author Information
1. 山东大学附属省立医院儿科
- Keywords:
Airway epithelial cells;
Asthma;
Mucous metaplasia
- From:
International Journal of Pediatrics
2017;44(10):671-674
- CountryChina
- Language:Chinese
-
Abstract:
Airway epithelial cells,which are the first line of defense against inhaled pathogens and parti-cles,play an important role in initiating airway inflammation,mucous metaplasia and keeping type 2 inflamma-tion in asthma.Mucous metaplasia of airway epithelial cells is one of the important part of airway reconstitution. The mucous overproduction in small airway leads to mucous plug,which is closely related to the high mortality of asthma.Multiple signaling and transcriptional networks influence goblet cell differentiation.These include JAK and the transcription factor STAT6,Notch,EGFR,et al.In this article,the changes of epithelial cells in asthma and its role at the beginning of asthma are described.Furthermore,the progress in airway mucous metaplasia and several related cell signaling pathways were focused on,which may provide some potential target to inhibit the secretion of mucous in asthma.
