rs12122341 polymorphism is not associated with risk of ischemic stroke in Chinese Han population
10.3760/cma.j.issn.1673-4165.2017.08.006
- VernacularTitle:rs12122341多态性与中国汉族人缺血性卒中发病风险无关
- Author:
Fang LI
1
;
Changhe SHI
;
Mibo TANG
;
Shuo LI
;
Shaohua LI
;
Shuo ZHANG
;
Zhijie WANG
;
Bo SONG
;
Yuming XU
Author Information
1. 450000,郑州大学第一附属医院神经内科
- Keywords:
Stroke;
Brain Ischemia;
Polymorphism,Genetic;
Genetic Predisposition to Disease;
Risk Factors
- From:
International Journal of Cerebrovascular Diseases
2017;25(8):724-728
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate correlation between the rs12122341 polymorphism and ischemic stroke and its major subtypes in Chinese Han population.Methods The patients with ischemic stroke and matched healthy controls in Chinese Han population were enrolled.The rs12122341 genotype was detected by the improved multiple ligase detection reaction (iMLDR).Results A total of 776 patients with ischemic stroke (415 large artery atherosclerotic stroke and 361 small artery occlusive stroke) and 776 healthy controls were enrolled.Genotyping showed that only rs12122341 CC and CG genotypes were detected in all subjects,and no GG genotype was detected.There was no significant difference in frequencies of allele and genotype between the patient group and the control group.Multivariate logistic regression analysis showed that there were no significant correlations between rs12122341 polymorphism and ischemic stroke (odds ratio [OR] 1.482,95％ confidence interval [CI]0.641-3.421;P =0.447),large artery atherosclerotic stroke (OR 1.972,95％ CI 0.655-6.034;P=0.227),and small arterial occlusive stroke (OR 1.632,95％ CI 0.437-6.262;P =1.000).Conclusions There is no significant correlation between the rs12122341 polymorphism and risk of ischemic stroke and its major subtypes in Chinese Han population.
