SOX4 gene and lung development
10.3760/cma.j.issn.1673-4408.2017.10.009
- VernacularTitle:SOX4基因与肺发育
- Author:
Bingting PAN
1
Author Information
1. 中国医科大学附属盛京医院新生儿科
- Keywords:
SOX4;
TGF-β;
Wnt;
EZH2;
lung development
- From:
International Journal of Pediatrics
2017;44(10):689-691,696
- CountryChina
- Language:Chinese
-
Abstract:
SOX4 is a member of the group C subfamily of the SOX transcription factors and has a criti-cal role during embryogenesis and in controlling cell fate.SOX4 can participate in TGF-β,Wnt signaling ways to mediate cell differentiation,proliferation,migration.SOX4 can facilitate epithelial-mesenchymal transition by di-rectly regulating EZH2 expression.It is one of the 64 genes that constitute a general signature in all human canc-ers.SOX4 is widely expressed in lung and establishes the lung structure in lung development.Here,we provide an overview of role of SOX4 in cell and lung development.
