Mechanisms of tubulo-epithelial-mesenchymal transition in renal interstitial fibrosis
10.3760/cma.j.issn.1673-4408.2017.10.010
- VernacularTitle:肾小管上皮细胞-间充质转分化在肾间质纤维化中的机制
- Author:
Jing XIAO
1
Author Information
1. 中国医科大学附属第一医院儿科
- Keywords:
Tubulo-epithelial-mesenchymal transition;
renal interstitial fibrosis;
mechanism research;
miRNA
- From:
International Journal of Pediatrics
2017;44(10):692-696
- CountryChina
- Language:Chinese
-
Abstract:
Tubulo-epithelial-mesenchymal transition refers to the renal tubular epithelial cells transfor-mation into stromal cells through some regulatory factors,causing tissue pathological changes.More and more scholars believe that EMT plays a crucial role in the development and metastasis of renal interstitial fibrosis.As an important small RNA related to gene transcription regulation,miRNA has a close relationship with EMT-relat-ed gene expression and plays an important role in EMT,and has become a hotspot in EMT.The research progress of recent years is reviewed in this passage.
