Biological characteristics and lymph node metastasis in papillary thyroid microcarcinoma
10.3760/cma.j.issn.1007-631X.2017.10.018
- VernacularTitle:甲状腺微小乳头状癌临床生物学特性及颈部淋巴结转移危险因素分析
- Author:
Xiaojing LI
1
;
Yumei ZHENG
;
Binlin MA
Author Information
1. 新疆医科大学附属肿瘤医院乳腺头颈外科
- Keywords:
Thyroid neoplasms;
Carcinoma,papillary;
Neoplasm metastasis;
Risk factors;
Neck dissection
- From:
Chinese Journal of General Surgery
2017;32(10):858-862
- CountryChina
- Language:Chinese
-
Abstract:
Objective To determine the correlation between biological characteristics and neck lymph node metastasis in papillary thyroid microcarcinoma (PTMC).Methods Clinical biological data were collected from patients first diagnosed with PTMC at the Xinjiang Medical University Affiliated Tumor Hospital from January 2010 to March 2016.Chi-square test and multivariate logistic regression analysis were used to identify risk factors of neck lymph node metastasis.Results With regard to clinical biological features of patients with PTMC,the male to female ratio is 1 ∶ 4.4.TNM stage Ⅰ accounted for 81.6％ in 1 622 cases,stage Ⅲ in 285(14.3％),stage ⅣA in 78(3.9％),stage ⅣB in 1 (0.05％),stage ⅣC in 2(0.1％) patients.All in all,34.9％ patients had the neck central lymph node metastasis.Multivariate logistic regression analysis indicated that age at diagnosis ＜45 years (P ＜0.001,OR =0.602),maleness (P ＜ 0.001,OR =0.473),tumor number≥3 (P =0.008,OR =1.843),tumor size ＞ 5 mm (P ＜ 0.001,OR =2.571),capsular invasion (P =0.035,OR =1.571),extrathyroidal extension (P =0.005,OR =1.834) were independently correlated with the neck lymph node metastasis.Conclusions An increased risk of the neck lymph node metastasis are seen in PTMC patients with male gender,age ＜ 45 years,tumor number ≥3,tumor size ＞ 5 mm,capsular invasion and extrathyroidal extension.
