The expression and significance of hypoxia-inducible factors-1α and pyruvate kinase type M2 in gastric carcinoma patients with Hp infection
10.3760/cma.j.issn.1007-631X.2017.10.022
- VernacularTitle:低氧诱导因子1α和M2型丙酮酸激酶在幽门螺杆菌感染胃癌组织中的表达及其意义
- Author:
Jiawei ZHANG
1
;
Bo CHEN
;
Kongwang HU
;
Maoming XIONG
Author Information
1. 安徽医科大学第一附属医院胃肠外科
- Keywords:
Stomach neoplasms;
Pyruvate kinase;
Helicobacter pylori;
Hypoxia-inducible factors
- From:
Chinese Journal of General Surgery
2017;32(10):875-878
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the expression of hypoxia-inducible factors-1 α and pyruvate kinase type M2 in Hp infected gastric carcinoma and their clinical significances.Methods The expression levels of hypoxia-inducible factors-1α and pyruvate kinase type M2 in 85 cases of gastric carcinoma tissues were detected by using RT-PCR and immunohistochemical method.The Virulence level of CagA gene were detected in Hp infected gastric tissue.Results As the degree of tumor differentiation,invasion depth and clinical stage of tumor increased,the positive expression rate of HIF-1 α and PKM2 increased,and the expression level of the two was in positive correlation.The positive expression rate of HIF-1α (73％)was related to lymph node metastasis (x2 =4.204,P =0.041).The positive expression rate of PKM2 (85 ％)was related to tumor diameter.The positive expression rate of HIF-1α and PKM2 (75％ and 85％,respectively)significantly increased in Hp infected gastric carcinoma tissue (x2 =6.486,P =0.010;x2 =7.341,P =0.009,respectively) and related to CagA + type.Conclusion HIF-1α and PKM2 may be closely correlated to development and metastasis of gastric carcinoma with Hp infection.
