The clinical significance of lymphovascular invasion in gastric cancer tissues

VernacularTitle:胃癌手术标本中脉管癌栓的临床意义
Author: Zaisheng YE ¹ ; Shenghong WEI ; Zhenmeng LIN ; Yi WANG ; Yi ZENG ; Yangming LI ; Jun XIAO ; Luchuan CHEN
Author Information

1. 福建医科大学附属肿瘤医院胃肠外科
Keywords: Stomach neoplasms; Neoplasm metastasis; Pathology,clinical; Prognosis
From: Chinese Journal of General Surgery 2017;32(10):816-819
CountryChina
Language:Chinese
Abstract: Objective To analyze the relationship of lymphovascular invasion (LVI) and the clinical pathological feature of gastric cancer and impact on the prognosis in gastric cancer patients.Methods The clinical and pathological data of 1 482 gastric cancer patients undergoing gastrectomy were analyzed retrospectively.The relationship between LVI and the prognosis was evaluated.Results LVI was found in 606 patients (40.9％),which was in significant correlations with tumor size,tumour location,Borrmann type,tumor differentiation status,operative method,tumor invasion,lymph node involvement,and TNM stage (P ＜ 0.05).The five-year survival of patients with LVI was significantly shorter than that of the LVI-negative patients (55.0％ vs.73.1％,x2 =45.15,P =0.00).By multivariate analysis,LVI was an independent prognostic factor (HR =1.592,95％ CI:1.329-1.907,P =0.00).Conclusion LVI is au important indicator for poor prognosis of gastric cancer,suggesting a more aggressive postoperative therapies.