Clinical study on the liver stiffness value measured by FibroScan and aspartate transaminase-to-platelet ratio index for evaluation of hepatic fibrosis in patients with chronic hepatitis B
10.3760/cma.j.issn.1000-6680.2017.08.004
- VernacularTitle:采用FibroScan和天冬氨酸转氨酶与血小板比值指数评估慢性乙型肝炎患者肝纤维化程度
- Author:
Rongrong DING
1
;
Wei LU
;
Yanbing WANG
;
Xinlan ZHOU
;
Xiufang LI
;
Dan HUANG
;
Zhanqing ZHANG
;
Guangfeng SHI
Author Information
1. 201508,上海市公共卫生临床中心肝炎二科
- Keywords:
Hepatitis B,chronic;
Liver stiffess measurement;
AST-to-PLT ratio index;
Liver fibrosis
- From:
Chinese Journal of Infectious Diseases
2017;35(8):467-471
- CountryChina
- Language:Chinese
-
Abstract:
Objective To assess the clinical diagnostic performance of liver stiffness measurement (LSM) and aspartate transaminase (AST)-to-platelet (PLT) ratio index (APRI) for liver fibrosis in chronic hepatitis B (CHB) patients with alanine aminotransferase (ALT) less than or equal to five times of the upper limit of normal (≤5×upper limit of normal [ULN]).Methods FibroScan,blood routine and liver function test were conducted at the day or one day before liver biopsy in 383 CHB patients with ALT≤5 × ULN.The Scheuer scoring system was used for liver histologic assessment.APRI was calculated.Based on the results of liver pathology,the areas under receiver operating characteristic curve (AUC) of LSM and APRI for diagnosis of liver fibrosis stage were compared.Results The median LSM were 5.10 kPa for S0 fibrosis stage,5.20 kPa for S1,6.60 kPa for S2,10.10 kPa for S3,and 18.80 kPa for S4.The median APRI values were 0.36,0.38,0.63,0.61 and 1.27,respectively.The AUC of LSM were 0.817 for ≥S2,0.891 for ≥S3 and 0.913 for ≥S4.And the AUC of APRI were 0.717 for ≥S2,0.711 for ≥S3 and 0.746 for ≥S4.The cut-offs of LSM values were 6.8 kPa for ≥S2,8.7 kPa for ≥S3,and 10.9 kPa for ≥S4.Conclusion LSM can accurately assess the degree of liver fibrosis in CHB patients with ALT ≤5 × ULN,which is superior to APRI in clinical utility.
