Expression regulation and forensic application of Brain Natriuretic Peptide
10.03618/j.issn.1001-5728.2017.05.008
- VernacularTitle:脑钠尿肽的表达调控机制及其法医学应用
- Author:
Meihui TIAN
1
;
Zhipeng CAO
;
Xinyi LUO
;
Jiajia XUE
;
Ying XIAO
;
Yuqing JIA
;
Baoli ZHU
Author Information
1. 中国医科大学法医学院
- Keywords:
forensic pathology;
brain natriuretic peptide;
expression regulation;
sudden cardiac death
- From:
Chinese Journal of Forensic Medicine
2017;32(5):472-475
- CountryChina
- Language:Chinese
-
Abstract:
Brain natriuretic peptide (BNP), a natriuretic peptide hormone, is mainly secreted by cardiomyocytes when they are pulled by mechanical force. BNP acts to increase natriuresis and decrease vascular resistance, thereby decreasing blood volume, systemic blood pressure and afterload. It is not only the main indicators of cardiac function which is widely used in clinical, recent studies have also shown that it has a very important value in identifying sudden cardiac death(SCD). However, the exact expression of the regulation mechanism is still unknown. This paper reviewed the structure, expression of the regulation mechanism of BNP, and the application progress in clinical and forensic.
