Research progress in the application of next-generation sequencing in forensic genetics
10.03618/j.issn.1001-5728.2017.05.010
- VernacularTitle:二代测序技术在法医遗传学中的应用研究进展(2011~2016)
- Author:
Baonian LIU
1
;
Yaqi ZHANG
;
Chengchen SHAO
;
Yueqin ZHOU
;
Jianhui XIE
Author Information
1. 复旦大学基础医学院法医学系
- Keywords:
forensic biological evidence;
next-generation sequencing technology;
genetic markers;
analysis software;
nomenclature
- From:
Chinese Journal of Forensic Medicine
2017;32(5):480-483,487
- CountryChina
- Language:Chinese
-
Abstract:
DNA typing of biological samples is an important step in performing individual identification and paternity testing in forensic applications. In practice, the detection of complex biological samples and the identification of complex kinships are challenging current biological technologies. Novel DNA technologies are also introduced into forensic genetics to improve the power of analysis. Next-generation sequencing (NGS) has several advantages, such as high-throughput and low cost, and can obtain detailed DNA sequences and relative contents of targeted regions, which will improve the detection of biological samples to help the analysis of forensic cases. The application of NGS in forensic genetics has received extensive attention and reports on the application of NGS in forensic genetics are increasing. In this study, we summarized the progress in the application research of NGS in the forensic genetics including the detection of genetic markers and their analytical methods. This will provide guides for related studies and forensic applications.
