G protein coupled receptors signaling pathways implicate in inflammatory and immune response of rheumatoid arthritis
10.3867/j.issn.1000-3002.2017.10.040
- Author:
SHU JIN-LING
1
;
ZHANG FENG
;
ZHANG LING-LING
;
WEI WEI
Author Information
1. Institute of Clinical Pharmacology
- Keywords:
GPCRs;
signaling pathway;
regulatory proteins;
rheumatoid arthritis
- From:
Chinese Journal of Pharmacology and Toxicology
2017;31(10):970-970
- CountryChina
- Language:Chinese
-
Abstract:
G protein coupled receptors (GPCRs) are transmembrane receptor proteins, which allow signals to transfer across membrane. GPCRs include a large number of receptors, different receptors mediated different signaling pathways of GPCRs- adenylyl cyclase (AC)- cyclic adenosine 3' ,5'-monophosphate (cAMP), including β2 adrenergic receptors (β2- ARs)- AC- cAMP signaling pathways, E-prostanoid2/4 (EP2/4)-AC-cAMP signaling pathways. Regulatory proteins, such as G protein coupled receptor kinases (GRKs) and β-arrestins, play important modulatory roles in GPCRs signaling pathway. GPCRs signaling pathway and regulatory proteins implicate the pathogenesis process of inflammatory and immune response. Rheumatoid arthritis (RA) is an autoimmune disease characterized by synovitis and accompanied with inflammatory and abnormal immune response. This article review the advances on GPCRs signaling pathway implicating in the inflammatory and immune response of RA.
