The Prognostic Role of the Surgical Approach and Adjuvant Therapy in Operable Mucosal Melanoma of the Head and Neck.
- Author:
GilJoon LEE
1
;
Chung Hwan BAEK
;
Na Yeon CHOI
;
Man Ki CHUNG
Author Information
- Publication Type:Original Article
- Keywords: Mucosal Melanoma; Head and Neck; General Surgery; Prognosis; Radiotherapy
- MeSH: Classification; Disease-Free Survival; Head*; Humans; Melanoma*; Neck*; Neoplasm Metastasis; Prognosis; Radiotherapy; Radiotherapy, Adjuvant; Recurrence; Reoperation; Retrospective Studies
- From:Clinical and Experimental Otorhinolaryngology 2017;10(1):97-103
- CountryRepublic of Korea
- Language:English
- Abstract: OBJECTIVES: The aim of this study was to investigate the prognostic impact of the surgical approach and adjuvant treatment in operable malignant melanoma of head and neck (MMHN). METHODS: Retrospective reviews of 31 patients who underwent surgery-based treatment with curative intent, either by the endoscopic or external approach, for MMHN were performed to analyze recurrence patterns, salvage modalities, and oncological outcomes (disease-specific survival and disease-free survival). RESULTS: Overall recurrence rate was 61% (19/31). In stage III patients (n=24), 50% (12/24) developed recurrences with a median recurrence-free period of 6.0 months, and 30% (4/12) of them was successfully salvaged by reoperation with adjuvant radiotherapy. On the contrary, all stage IVA patients (n=7) developed recurrences with a median recurrence-free period of 4.4 months. Distant metastasis was the most common pattern of failure and no patients were salvaged. Among variables, age and T classification, not the surgical approach, were significant prognosticators for disease-free survival and disease-specific survival. Adjuvant radiotherapy was associated with a lower rate of local failure, compared to surgery alone (hazard ratio, 0.02; 95% confidence interval, 0.06 to 0.75; P=0.02). However, adjuvant systemic therapy was not effective in reducing the risk of failures for any pattern. CONCLUSION: Our data suggested that meticulous surgical resection, either by the endoscopic or external approach, with adjuvant radiotherapy increases the local control rate in MMHN.
