The relationship between DNA methylation profile of peripheral blood and smoking
10.03618/j.issn.1001-5728.2017.05.017
- VernacularTitle:外周血DNA甲基化谱与吸烟的关系
- Author:
Gang BI
1
;
Yu CAO
;
Wei HU
;
Weiwei SHENG
;
Huaigu ZHOU
;
Yun LIU
Author Information
1. 上海市公安局物证鉴定中心
- Keywords:
forensic biological evidence;
methylation;
individual identification;
smoking population
- From:
Chinese Journal of Forensic Medicine
2017;32(5):508-511
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the potential application of separating smoking individuals from non-smoking ones by DNA methylation profiles from peripheral blood. Methods Human genome-wide DNA methylation data were downloaded from NIH GEOdata base. DNA methylation values from certain CpG sites were used to evaluate their significance between smokers and non-smokers by Student's T Test, as well as the clustering analysis. Results There are significant DNA methylation between smokers and non-smokers for certain CpGs. Conclusion Detection of methylation status from human peripheral blood can distinguish smokers from non-smokers.
