Rapid screening of 3 synthetic cannabinoids in blood by direct analysis in real time mass spectrometry

VernacularTitle:DART-MS/MS快速检测人血中的3种合成大麻素
Author: Tao MIN ¹ ; Ying ZHANG ; Shaodan LIU ; Daming ZHANG
Author Information

1. 山西医科大学法医学院
Keywords: forensic toxicological analysis; direct analysis in real-time mass spectrometry; synthetic cannabinoids; rapid screening
From: Chinese Journal of Forensic Medicine 2017;32(4):388-392
CountryChina
Language:Chinese
Abstract: Objective To establish a method for rapid detection of JWH-018, JWH-250 and AM-2201 in blood by direct analysis in real-time coupled with tandem mass spectrometry. Methods These samples were extracted by acetonitrile-methanol (4:1), using DART 12Dip-it automatic sampling system. They were analyzed by positive ion and MRM mode. Results The detection limits of JWH-018, JWH-250 and AM-2201 were in good linearity in the range of 0.02-5.00μg/mL. The correlation coefficients were above 0.99 and the detection limits were 0.016μg/mL, 0.003μg/ mL and 0.017μg/mL, respectively. The intra-day and inter-day RSD were less than 15%. Conclusion The method has the advantages of high sensitivity and good accuracy. The sample processing is simple and can be analyzed in short time. This method is suitable for the analysis of JWH-018, JWH-250 and AM-2201 in practical cases.