TACE combined with radiofrequency ablation for primary hepatocellular carcinoma exceeding Milan liver transplantation standard: comparative study of therapeutic evaluation between mRECIST criterion and RECIST criterion
10.3969/j.issn.1008-794X.2017.10.007
- VernacularTitle:TACE联合射频消融治疗超米兰标准原发性肝癌疗效评价的比较研究
- Author:
Jia LIU
1
;
Chunsheng NIE
;
Shiqian LIU
;
Dongfeng HE
;
Ruibao LIU
Author Information
1. 150081,哈尔滨医科大学附属肿瘤医院介入科
- Keywords:
mRECIST criterion;
beyong Milan criterion;
primary hepatocellular carcinoma
- From:
Journal of Interventional Radiology
2017;26(10):889-893
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the consistency of mRECIST criterion and RECIST criterion in evaluating the curative effect of transcatheter arterial chemoembolization (TACE) combined with radiofrequency ablation (RFA) for primary hepatocellular carcinoma (PHC) which condition exceeds Milan liver transplantation standard in order to determine which criterion can evaluate the curative effect better.Methods A total of 78 PHC patients,whose lesion's extent exceeded Milan standard and who had received TACE combined with RFA therapy,were included in this study.The curative effect was separately evaluated by mRECIST criterion and RECIST criterion.KAPPA coefficient was calculated to determine the consistency of the evaluation results by the two criteria.By using Kaplan-Mier method,the median survival time (MST) of patients achieving different remission degree was calculated.Log-rank test was used to draw survival curve.The MST and the survival curve of patients with different remission degree were statistically compared between the two criteria.Results By using SPSS19.0 software,the KAPPA coefficient of the evaluation results of the two criteria was 0.243 (x2=5.250,P＜0.01).The MST of patients,which was calculated by Kaplan-Mier method,had multiple overlapping parts with SD and PR curves that were drawn by log-rank test based on RECIST criterion,the difference between the two was not statistically significant (P＞0.05).When mRECIST criterion was based on,the survival curve of patients with different remission degree was relatively balanced and showed no overlapping parts,the difference between the two was statistically significant (P＜0.01).Conclusion (1) The mRECIST criterion is not suitable for the evaluation of the curative effect of PHC patients whose lesion's extent exceeds Milan standard,and mRECIST criterion can not apply to make evaluation of the curative effect for PHC when the lesion's border is unclear and its enhancement is not obvious.(2) mRECIST criterion can more accurately evaluate the curative effect of TACE combined with PRA in treating PHC which extent exceeds Milan liver transplantation standard.
