18F-Fluorodeoxyglucose positron emision tomography in the assessment of disease activity of Takayasu arteritis: a meta-analysis
10.3760/cma.j.issn.1007-7480.2017.10.003
- VernacularTitle:18氟-脱氧葡萄糖-正电子发射计算机断层扫描对大动脉炎疾病活动性诊断和评估的Meta分析
- Author:
Zongfei JI
1
;
Xiaomin DAI
;
Lili MA
;
Taoying GU
;
Xiufang KONG
;
Lingying MA
;
Huiyong CHEN
;
Lindi JIANG
Author Information
1. 200032上海,复旦大学附属中山医院风湿免疫科,复旦大学风湿、免疫、过敏中心,复旦大学循证医学中心
- Keywords:
Takayasu arteritis;
Positron emision tomography/CT;
Meta analyse
- From:
Chinese Journal of Rheumatology
2017;21(10):657-662,721
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the performance of Positron emision tomography (PET) in the assessment of disease activity of Takayasu arteritis (TA). Methods Information retrieval was based on database such as PubMed/Medline and CNKI, etc. The research before Dec 2016 involving Takayasu arteritis and PET were included.The quality of the research was evaluated by diagnostic accuracy studies-2Q(UADAS-2) and the data was analyzed by Meta-disc. Results Among the 70 research, nine studies were included in this study with a total of 126 patients and 254 controls. All patients were diagnosed according to the classification criteria of American College of Rheumatology. The disease activity was mostly assessed by the scoring system of National Institutes of Health and by clinical assessment in one study. The result of PET was evaluated by visual grade and semi-quantitative analysis. The pooled DOR of the 9 studies was 17.54, the pooled sensitivity and specificity was 84% and 73%,respectively.However,the heterogeneity of specificity was 81.4%. Two studies had included one patients repeatedly and suspected active patients were included in the in-active group in one study,which might impact the statistical result of the meta-analysis.After excluded these studies, the pooled DOR was 30.32. The pooled sensitivity and specificity was 86% and 85%, respectively, with better consistency. Conclusion PET shows stable sensitivity and variant specificity in the diagnosis and assess of disease activity of TA, which is a useful method in the clinically evaluation of disease activity of TA.
