Effects of different target plasma concentrations of propofol on ventricular repolarization in elderly patients
10.3760/cma.j.issn.0254-1416.2017.08.003
- VernacularTitle:不同血浆靶浓度丙泊酚对老年患者心室复极的影响
- Author:
Chunlei WEN
1
;
Hong GAO
;
Yanqiu LIU
;
Jie LYU
;
Kaiqiang ZHANG
;
Juan LEI
Author Information
1. 贵州医科大学麻醉学院
- Keywords:
Aged;
Propofol;
Electrocardiography
- From:
Chinese Journal of Anesthesiology
2017;37(8):907-909
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effects of different target plasma concentrations of propofol on ventricular repolarization in elderly patients.Methods Forty-five patients,aged 65-80 yr,weighing 43-85 kg,of American Society of Anesthesiologists physical status Ⅰ or Ⅱ,scheduled for elective surgery under general anesthesia,were divided into 3 groups (n=15 each) using a random number table:propofol at target plasma concentration of 2 μg/ml group (group P1),propofol at target plasma concentration of 3 μg/ml group (group P2) and propofol at target plasma concentration of 4 μg/ml group (group P3).Before induction of anesthesia (T1) and at 5 min after propofol reached the target plasma concentration (T2),12-lead electrocardiogram was recorded,the QT and Tp-e intervals were measured,and the corrected QT (QTc) interval and Tp-e/QT ratio were calculated.Results There were no significant differences in QTc interval,Tp-e interval or Tp-e/QT ratio at T1,2 between the three groups (P＞0.05).Compared with those at T1,the QTc and Tp-e intervals were significantly shortened and the Tp-e/QT ratio was decreased at T2 in P1 and P2 groups,and the Tp-e interval was shorten and the Tp-e/QT ratio was decreased at T2 (P＜ 0.05),and no significant change was found in the QTc interval at T2 in group P3 (P＞0.05).Conclusion Propofol at clinically relevant concentrations can shorten the ventricular repolarization in elderly patients.
