Relationship between anesthesia factors and postoperative cognitive dysfunction in elderly patients with metabolic syndrome: propofol-based anesthesia versus sevoflurane-based anesthesia
10.3760/cma.j.issn.0254-1416.2017.08.004
- VernacularTitle:麻醉因素与代谢综合征老年病人术后认知功能障碍的关系:异丙酚复合麻醉与七氟醚复合麻醉比较
- Author:
Hanyue ZHU
1
;
Jingjing LI
;
Liqin DENG
;
Fengxiang SONG
;
Haiying ZHAO
;
Gang CHEN
Author Information
1. 宁夏医科大学临床医学院麻醉系
- Keywords:
Propofol;
Anesthetics,inhalation;
Metabolic syndrome X;
Aged;
Cognition disorders
- From:
Chinese Journal of Anesthesiology
2017;37(8):910-913
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the effects of propofol-based anesthesia versus sevoflurane-based anesthesia on postoperative cognitive dysfunction (POCD) in elderly patients with metabolic syndrome.Methods Ninety-four patients of both sexes,aged 65-80 yr,weighing 60-95 kg,of American Society of Anesthesiologists physical status Ⅱ or Ⅲ,scheduled for elective orthopedic surgery or gastrointestinal surgery under general anesthesia,were assigned to either propofol-based anesthesia group (group P,n =47) or sevoflurane-based anesthesia group (group S,n =47) using a random number table.Anesthesia was maintained by Ⅳ infusion of propofol 4-6 mg · kg-1 · h-1 in group P and by inhalation of 1％-2％ sevoflurane in group S.The bispectral index value was maintained between 40-60 during surgery.Cognitive function was evaluated using the Mini-Mental State Examination,trial making test and Digit Span Tests Forward and Backward at 1 day before surgery and 3 and 7 days after surgery.The occurrence of POCD was recorded at 3 and 7 days after surgery.Results There were no significant differences in Mini-Mental State Examination scores,trial making test time,Digit Span Tests Forward and Backward scores or incidence of POCD between group S and group P (P＞0.05).Conclusion The effects of propofol-based anesthesia and sevoflurane-based anesthesia on POCD are comparable in elderly patients with metabolic syndrome.
