Changes in platelet activity during perioperative period in patients with diabetes mellitus
10.3760/cma.j.issn.0254-1416.2017.08.006
- VernacularTitle:糖尿病患者围术期血小板活性的变化
- Author:
Minghui ZHENG
1
;
Lijun ZHAO
;
Zheng GUO
Author Information
1. 山西医科大学麻醉学系
- Keywords:
Diabetes mellitus;
Intraoperative period;
Blood platelets
- From:
Chinese Journal of Anesthesiology
2017;37(8):918-920
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the changes in the platelet activity during the perioperative period in the patients with diabetes mellitus.Methods Twenty patients with type 2 diabetes mellitus (group DM) and 22 patients with no diabetes mellitus (group NDM) of both sexes,with body mass index of 20-30 kg/m2,of American Society of Anesthesiologists physical status Ⅰ or Ⅱ,scheduled for elective spinal or hip joint surgery,were enrolled in the study.Blood samples were collected on admission to the operating room (T0),immediately after recovery from general anesthesia (T1) and at 24 h after surgery (T2).The expression of platelet P-selectin (CD62P) was measured by flow cytometry,and the positive rate was calculated.The platelet count (PLT) and mean platelet volume (MPV) were determined using an automatic blood cell analyzer.Results Compared with group NDM,the positive rate of CD62P cells at T0.1 and PLT at To were significantly increased (P＜0.05),and no significant change was found in MPV at each time point in group DM (P＞0.05).There was no significant difference in the positive rate of CD62P cells,PLT or MPV between each time point within each group (P＞0.05).Conclusion Platelets remain hyperactivity that is not further enhanced by diabetes mellitus during the perioperative period in the patients.
