Progress in IL-36 as a new target for the treatment of inflammatory diseases

VernacularTitle:IL-36作为炎症性疾病治疗新靶点的研究进展
Author: Xiaoying WANG ¹ ; Zhiyu LU ; Keye XU ; Yan LI ; Mingcai LI
Author Information

1. 315211,宁波大学医学院免疫学研究室
Keywords: Interleukin-36; Inflammation; Psoriasis; Inflammatory bowel disease
From: Chinese Journal of Microbiology and Immunology 2017;37(11):869-873
CountryChina
Language:Chinese
Abstract: Interleukin (IL)-36, a member of the IL-1 family, plays an important role in mediating inflammatory diseases .IL-36 subfamily consists of IL-36α, IL-36β, IL-36γand IL-36 receptor antagonists (IL-36Ra).IL-36 receptor (IL-36R) and IL-1 receptor accessory protein (IL-1RAcP) are involved in the IL-36-mediated signal transduction .In human, mutations in the gene encoding IL-36Ra will lead to IL-36R signaling disorders , mainly manifested as diffuse pustular psoriasis .It suggests that IL-36 plays an important role in psoriasis.Recently, it has also been found that IL-36 is related to inflammation in other organs . These emerging roles of IL-36 provide new thoughts for the treatment of human inflammatory diseases .