Role of immune cells in regulating chronic inflammation in adipose tissue

VernacularTitle:免疫细胞在调节脂肪组织慢性炎症中的功能
Author: Can YANG ¹ ; Zengyu ZHANG ; Xiangfeng SONG ; Lili YU
Author Information

1. 453003 新乡医学院基础医学院免疫学教研室,河南省免疫与靶向药物重点实验室, 河南省分子诊断与医学检测技术协同创新中心
Keywords: Adipose tissue; Chronic inflammation; Immune cell; Metabolism
From: Chinese Journal of Microbiology and Immunology 2017;37(11):879-884
CountryChina
Language:Chinese
Abstract: Inflammation is part of the body′s response to invading pathogens and a crucial process in the maintenance of homeostasis .A variety of regulatory mechanisms are involved in inflammation process to limit the damage caused by excessive immune response to the host .Previous studies have shown that insu-lin resistance , type 2 diabetes , liver fibrosis and cardiovascular disease are caused by persistent chronic in-flammation in metabolic tissue (brain, fat, liver, pancreas, etc), especially in adipose tissue.However, the underlying mechanisms of these conditions have not been fully understood .The role of innate and adap-tive immune cells in these diseases attracts increasing attention .In this review, we will focus on the role of various immune cells in adipose tissue in the initiation and development of inflammation and discuss the effi -cacy of potential anti-inflammatory therapies based on their mechanisms .