A retrospective cohort study on treatment ofTiaogan-Bushen-Xiaoji recipe for the patients with advanced breast cancer
10.3760/cma.j.issn.1673-4246.2018.01.005
- VernacularTitle:调肝补肾消积法治疗晚期乳腺癌临床研究
- Author:
Weiyu ZHANG
1
;
Xiaoheng SHEN
;
Lan ZHENG
;
Haifeng YING
;
Guyin LOU
;
Yuanbiao GUO
;
Weirong ZHU
;
Lingling LYU
Author Information
1. 200025,上海交通大学医学院附属瑞金医院中医科
- Keywords:
Breast neoplasms;
Antineoplastic drugs (TCD);
Triple-negative breast cancer;
Retrospective studies
- From:
International Journal of Traditional Chinese Medicine
2018;40(1):18-21
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the efficacy ofTiaogan-Bushen-Xiaoji recipe (TGBSXJ Recipe) on overall survival and progression free survival (PFS) in patients with advanced breast cancer.Methods A total of 105 patients with advanced breast cancer, who received the first-line treatment, were divided into two groups, 56 cases in the control group and 49 in the experimental group. The control group received standard therapy according to guidelines, including chemotherapy, targeted therapy, endocrine therapy and treatment of bisphosphonates.The experimental group received the treatment of TGBSXJ Recipe besides the standard therapy. The overall survival (OS), progression-free survival (PFS) and Karnofsky (KPS) of the patients in two groups were observed and compared. The treatment ended with the sighs of the observation ending, the second progress for the disease or death.Results The overall survival of the experimental group was significantly higher than that of the control group [OS: 58.2(50.7-65.8)/monthsvs. 43.8(30.6-51.6)/months,P=0.040]. The PFS of the experimental group was significantly higher than the control group [PFS: 30.7(23.8-37.7)/monthsvs. 15.2(11.3-19.1)/months,P=0.001]. The KPS of the experimental group was significantly higher than the control group (88.6 ± 10.0vs. 80.5 ± 19.0,t=2.654). The PFS of the triple negative breast cancer (TNBC) in the experimental group was significantly higher than control group [(25.1(12.1-38.0)/monthsvs. 9.9(4.7-15.0)/months,P=0.038].Conclusions The TGBSXJ recipe could extend the OS and PFS and improve the life quality of the patients with advanced breast cancer. In this study, no severe adverse effects had been found in the experimental group.
