Base excision repair and targeted therapy strategies
10.3760/cma.j.issn.1673-422X.2017.11.013
- VernacularTitle:碱基切除修复及其靶向治疗策略
- Author:
Tianqi ZHANG
1
;
Hongbing WANG
Author Information
1. 221000,徐州医科大学研究生学院
- Keywords:
DNA repair;
Polymorphism;
Genomic instability;
Base excision repair
- From:
Journal of International Oncology
2017;44(11):856-859
- CountryChina
- Language:Chinese
-
Abstract:
Base excision repair (BER) is an important pathway for DNA oxidative damage repair,and mutations in this pathway cause gene instability and increase cancer risk.A large number of studies have shown that abnormal expression of key proteins in the BER pathway in a variety of tumors,such as DNA glycosylase,apurinic/apyrimidinic endonuclease 1,DNA polymerase and so on.Single nucleotide polymorphisms of these proteins affect the repair activity of tumor cells,and are expected to be important indicators for the diagnosis,treatment and evaluation of prognosis.
