Clinical validation of the 2012 classification criteria for early rheumatoid arthritisin: a domestic multi-center cohort
10.3760/cma.j.issn.1007-7480.2017.12.004
- VernacularTitle:2012年早期类风湿关节炎分类标准的国内多中心临床验证
- Author:
Yucui LI
1
,
2
;
山西医学科学院山西大医院风湿免疫科
;
Wenqiang FAN
;
Haiying CHEN
;
Ping YU
;
Huali MIAO
;
Kunjie LI
;
Jinrong XU
;
Liufu CUI
;
Gailian ZHANG
Author Information
1. 100044 北京大学人民医院风湿免疫科
2. 山西医学科学院山西大医院风湿免疫科
- Keywords:
Arthritis,rheumatoid;
Diagnosis;
Reference standards
- From:
Chinese Journal of Rheumatology
2017;21(12):807-811
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the value of 2012 classification criteria for early rheumatoid arthritis (ERA),2010 American College of Rheumatology/European League Against Rheumatism (ACR/EULAR) classification criteria,and 1987 ACR classification criteria in the diagnosis of early rheumatoid arthritis (RA).Methods Patients who had at least one swollen and tender joint with disease duration no more than 2 years,and age more than 16 years were enrolled.The patients were diagnosed as RA or other non-RA by 2 experienced rheumatologists.The clinical and laboratory parameters were recorded.The sensitivity and specificity of three RA classification criteria were compared by McNemar test,The areas under the receiver operating characteristic curve (ROC) curve (AUC) of each RA classification criteria were analyzed using MedCalc software.Results Atotal of 310 patients were enrolled in this study,including 182ERA and 128 non-RA.The sensitivity(88.5％) of ERA criteria was much higher than that of the 1987 ACR criteria (45.6％,x2=75.013,P＜0.05),and not significantly different with the 2010 ACR/EULAR criteria (91.8％,X2=1.042,P＞0.05).The specificity of ERA criteria (91.4％) of 2010 ACR/EULAR criteria (87.5％,x2=1.8,P＞0.05) was similar to that of the 1987 ACR criteria (96.1％,x2=3.1,P＞0.05).The AUC of ERA criteria was 0.962 [95％CI(0.934,0.980)],which was slightly better than that of the 2010 ACR/EULAR criteria 0.959 [95％CI(0.931,0.978)],Z=0.380,P=0.7038,and much higher than that of the 1987 ACR criteria 0.885 [95％CI (0.845,0.919)],Z=4.517,P＜0.01.Conclusion Overall evaluation,the diagnostic value of ERA criteria is better than 1987 ACR and 2010 ACR/EULAR criteria in early rheumatoid arthritis.Compared to 2010 ACR/EULAR classification criteria,ERA criteria is more simple and practical.
