Construction strategy of nerve conduits bridging long peripheral nerve defects
10.3760/cma.j.issn.1673-4904.2017.12.024
- VernacularTitle:桥接长段周围神经缺损导管的构建策略
- Author:
Yiyong MA
1
,
2
;
锦州医科大学骨外科学研究所、辽宁省医学组织工程重点实验室
;
Wei WANG
Author Information
1. 121001 锦州医科大学附属第一医院骨科
2. 锦州医科大学骨外科学研究所、辽宁省医学组织工程重点实验室
- Keywords:
Peripheral nerve defect;
Nerve conduit;
Repair;
Construction strategy;
Review
- From:
Chinese Journal of Postgraduates of Medicine
2017;40(12):1142-1145
- CountryChina
- Language:Chinese
-
Abstract:
The repair, regeneration and functional recovery of peripheral nerve defects are the clinical problems needed to be solved urgently.Researches showed that the hollow conduits of bridging nerve defects only had the functions of support and isolation, but the composite conduits could simulate nerve regeneration microenvironment and possess biological activity, which could effectively guide the migration of Schwann cells and the regeneration of axons to achieve satisfactory effects of restoration and functional recovery.With the development of tissue engineering, regenerative medicine, biomaterial and the techniques of cells and molecular biology, the construction of biomimetic and functional nerve conduits to bridge long nerve defects has attracted more and more attention. This review will provide a brief overview of the construction strategy of nerve conduits repairing long nerve defects of peripheral nerves.
