Nuclear EGFR:a potential target for radiosensitizer
10.3760/cma.j.issn.1004-4221.2018.01.025
- VernacularTitle:核EGFR:潜在放疗增敏靶点研究进展
- Author:
Tingting ZHANG
1
;
Baocai LIU
;
Guanghui CHENG
Author Information
1. 吉林大学中日联谊医院放疗科
- Keywords:
Epidermal growth factor receptor;
Radiosensitivity;
Neoplasms/targeted therapy
- From:
Chinese Journal of Radiation Oncology
2018;27(1):116-120
- CountryChina
- Language:Chinese
-
Abstract:
Nuclear epithelial growth factor receptor (EGFR) plays an important role in the development, metastasis, treatment, and prognosis of cancer. Radiotherapy, one of the main therapies for malignant tumor, causes EGFR transfer into the nucleus along with tumor therapy, thereby reducing radiosensitivity. Insight into the biological characteristics and functions of nuclear EGFR has an important reference value for improving radiosensitivity. Therefore, this article elaborates on EGFR transport into the nucleus,the features of nuclear EGFR,and its relationship with radiosensitivity and clinical targeted therapy.
