Co-stimulating molecule B7-H3 and tumors

VernacularTitle:协同刺激分子B7-H3与肿瘤
Author: Xiaowen ZHU ¹ ; Jing WANG ; Xiaoyan KE
Author Information

1. 100191,北京大学第三医院血液科
Keywords: Neoplasms; Co-stimulatory molecule B7-H3
From: Journal of International Oncology 2017;44(11):849-852
CountryChina
Language:Chinese
Abstract: B7-H3,a newly discovered co-stimulatory regulatory protein member of the B7 family.Its mRNA is ubiquitously expressed in a wide spectrum of tissues.As a co-stimulatory or co-inhibitory signal molecule which can regulate immune response,B7-H3 plays an important role in the immune system.Besides,B7-H3 can be also involved in cancer progression via non-immunological.Recently,the aberrant expression of B7-H3 has been described in various malignancies,and significantly correlated with poor prognosis and cancer progression.Therefore,B7-H3 is considered as an early diagnostic and prognostic marker and therapeutic target for tumors,but the specific molecular mechanisms of B7-H3 regulation are poorly understood.The immune and gene therapy of tumor by target B7-H3 has made some progress.