Efficacy and safety of duloxetine versus sertraline for Chinese depression patients: a meta-analysis
10.3760/cma.j.issn.1671-7368.2018.01.011
- VernacularTitle:度洛西汀与舍曲林治疗中国抑郁症患者疗效及安全性Meta分析
- Author:
Keyang CHEN
1
;
Songfang CHEN
;
Hanjin HUANG
;
Xiaotong WANG
Author Information
1. 325027,温州医科大学附属第二医院神经内科
- Keywords:
Duloxetine;
Sertraline;
Depression;
Randomized controlled trial;
Meta-analysis
- From:
Chinese Journal of General Practitioners
2018;17(1):50-55
- CountryChina
- Language:Chinese
-
Abstract:
Objective To systematically evaluate the efficacy and safety of duloxetine and sertraline for Chinese depression patients.Methods The randomized controlled trials(RCTs)comparing the efficacy and safety of duloxetine and sertraline in the treatment of depression were retrieved from databases and the quality of literature was evaluated.Meta-analysis was performed with the software Revman 5.2.Results Eighteen RCTs involving 1 557 Chinese depression patients were included.The results of Meta-analysis showed that there were no significant differences in efficacy and cure rate between duloxetine and sertraline groups(OR=1.28, 95%CI:0.94 -1.73, P =0.11; OR =1.25,95%CI:0.97 -1.62,P =0.09, respectively).The Hamilton Depression Scale(HAMD)scores were significantly lower in duloxetine group than those in sertraline group at 1,2 weeks after treatment;however,there were no significant differences at 8-weeks after treatment between duloxetine and sertraline groups.The score of Medical Outcomes Study Pain Measures(MOSPM)in duloxetine group was significantly lower than that in sertraline group(P<0.01). The rate of insomnia in duloxetine group was significantly lower than that in sertraline group(RR=0.57, 95%CI:0.32 -1.00, P=0.04).There were no significant differences in other common side reactions between the two groups(P>0.05).Conclusions Duloxetine has similar long term treatment effect as sertraline,but it has a rapid-action profile.Duloxetine is more effective than sertraline in depression with painful physical symptoms;besides,duloxetine is less likely to induce insomnia.
