Outcomes of alternative donor allogeneic hematopoietic stem cell transplantation for Fanconi anemia:a five cases report
10.3760/cma.j.issn.0578-1426.2018.01.010
- VernacularTitle:替代供者异基因造血干细胞移植治疗范可尼贫血五例分析
- Author:
Wenjing WANG
1
;
Yuqian SUN
;
Feifei TANG
;
Tingting HAN
;
Xiaodong MO
;
Jingzhi WANG
;
Xiaohui ZHANG
;
Xiaojun HUANG
;
Lanping XU
Author Information
1. 100044,北京大学人民医院 北京大学血液病研究所 造血干细胞移植治疗血液病北京市重点实验室
- Keywords:
Fanconi anemia;
Hematopoietic stem cell transplantation;
Haploidentical;
Matched unrelated donor
- From:
Chinese Journal of Internal Medicine
2018;57(1):54-56
- CountryChina
- Language:Chinese
-
Abstract:
Five patients with Fanconi anemia who received hematopoietic cell transplantation were retrospectively analyzed. The conditioning regimens included fludarabine, cyclophosphamide and anti-thymocyte globulin. Two patients received both bone marrow and peripheral blood stem cells as the source of stem cell grafts from haploidentical matched related donors, while the others received peripheral blood stem cells from unrelated donors.All patients tolerated well and reached hematopoietic reconstitution. One patient died of intracranial infection.During follow-up,4 patients survived independent of transfusion with full donor chimerism.
