A Case of Refractory Headache with Antiphospholipid Antibody Syndrome Improved by High-Intensity Warfarin Medication.

Author: Kyung Hee CHO ¹ ; Jun Gyu YANG ; Ji Sun KIM ; Sung Wook LEE
Author Information

1. Department of Neurology, Korea University College of Medicine, Seoul, Korea. kh.cho.neuro@gmail.com
Publication Type:Case Report
Keywords: Antiphospholipid antibody syndrome; Headache; Warfarin
MeSH: Analgesics; Antibodies, Antiphospholipid; Antiphospholipid Syndrome*; Capillaries; Headache*; Humans; Microcirculation; Thrombophilia; Warfarin*
From:Journal of Rheumatic Diseases 2014;21(2):74-76
CountryRepublic of Korea
Language:Korean
Abstract: Antiphospholipid antibody syndrome (APS) is a coagulation disorder associated with antiphospholipid antibodies. Headache is common in APS patients and often unresponsive to analgesics. We report a case of refractory headache in a patient with APS, who was improved by high-intensity warfarin treatment. The mechanisms of the headache in patients with APS were presumed to be hypercoagulability of microcirculation and thrombotic occlusion of the capillaries, which were associated with antiphospholipid antibodies. Therefore, high-intensity warfarin could be considered as one of the treatments for refractory headache in patients with APS.