The protective effects of Hericium Tablets on acute alcoholic gastric mucosal injury in rats and its mechanism
10.3969/j.issn.1001-1528.2017.12.003
- VernacularTitle:猴头菌片对大鼠急性酒精性胃黏膜损伤的保护作用及其机制
- Author:
Qian WANG
1
;
jun Jia XIE
;
hua Ying ZHANG
;
wen Yi HUANG
;
fan Yi YANG
;
Meng CHEN
;
li Feng HU
;
Miao CHENG
;
Jing ZHANG
Author Information
1. 上海中医药大学药物安全评价研究中心
- Keywords:
Hericium Tablets;
alcohol;
gastric mucosal injury;
aminohexose;
pepsin;
pH
- From:
Chinese Traditional Patent Medicine
2017;39(12):2454-2461
- CountryChina
- Language:Chinese
-
Abstract:
AIM To explore the protective effects of Hericium Tablets on the injury of gastric mucosa and to investigate its possible mechanism.METHODS The rats were orally given doses of Hericium Tablets (0.25,0.5,1.0 g/kg) once a day for seven days.One hour after the last doses,the rats were orally given a dose of anhydrous ethanol (5 mL/kg).In one hour,the degree of gastric mucosal injury and pathological changes were observed.Gastric juice pH and pepsin activity were detected by absorbing the gastric juice.The contents of amino hexose,PGE2 and IL-1β were detected by scraping gastric mucosa.RESULTS Hericium Tablets can obviously alleviate the damage degree of gastric mucosa,reduce the gastric mucosal hyperemia,bleeding,edema and necrosis,as well as against the decrease of pepsin activity in gastric juice,and the decrease of the content of amino hexose in gastric mucosal layer was inhibited,but there was no significant effect on the contents of PGE2 and IL-1 β and the increasement of pH value of gastric juice.CONCLUSION The effects of Hericium Tablets on gastric mucosal injury are obvious,and its mechanism is related to the decrease of the contents of gastric mucosa.
