A dosimetric analysis of combined intracavitary/interstitial brachytherapy for locally advanced cervical cancer
10.3760/cma.j.issn.0254-5098.2017.12.008
- VernacularTitle:局部晚期宫颈癌腔内放疗联合组织间插植的剂量学研究
- Author:
Yongxia ZHANG
1
;
Xiangkun YUAN
;
Fumin SHI
;
Jianwei HU
;
Lei GAO
;
Junjun MIAO
;
Xiaona ZUO
;
yuwei XIE
Author Information
1. 河北省沧州中西医结合医院放化疗科
- Keywords:
Cervical cancer;
Brachytherapy;
Intracavitary;
Interstitial interpolation;
Dosimetry
- From:
Chinese Journal of Radiological Medicine and Protection
2017;37(12):919-923
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the dosimetric differences between intracavitary brachytherapy in combination with interstitial brachytherapy or not for locally advanced cervical cancer.Methods From May 2016 to March 2017,35 patients with locally advanced cervical cancer treated with combined external beams and intracavitary/interstitial brachytherapy were selected in this study.The prescription of intensity-modulated radiation therapy was:46.8-50.4 Gy/26-28 fractions,1.8 Gy/fraction.The prescription for combined intracavitary/interstitial brachytherapy was 7 Gy/fraction × 4,once per week.Each patient was first implanted with a three tube applicator for brachytherapy,and the CT images were acquired for treatment planning.The three tube applicator was removed before a uterine tube and needles were implanted,thereafter planning images were acquired again.Dose to the targets and organs at risk were evaluated respectively for the two groups.Results A total of 212 brachytherapy plans were developed,including 106 intracavitary and 106 endoluminal combined interstitial plans.The target dose in endoluminal combined interstitial brachytherapy was significantly higher than that of intracavitary treatment alone,where D90 of the high-risk clinical target volume (CTV) and moderate CTV were both significantly increased (t =-6.01,-2.73,P ＜ 0.05).The D2 cm3 of the bladder,rectum and sigmoid colon were significantly reduced (t=3.07,4.52,2.91,P＜0.05).Conclusions The application of the endoluminal combined interstitial brachytherapy for locally advanced cervical cancer can significantly increase the target dose,and reduce the dose to organs at risk such as the bladder,rectum and sigmoid colon.
