Gushen Antai Pills combined with low-molecular-weight heparin treating prethrombotic state of women with recurrent spontaneous abortion
10.3969/j.issn.1001-1528.2017.12.007
- VernacularTitle:固肾安胎丸联合低分子肝素干预复发性流产妇女血栓前状态的疗效
- Author:
Ning HAN
1
;
juan Ya XU
Author Information
1. 郑州大学第三附属医院产科
- Keywords:
Gushen Antai Pills;
low-molecular-weight heparin;
recurrent spontaneous abortion;
prethrombotic state
- From:
Chinese Traditional Patent Medicine
2017;39(12):2481-2484
- CountryChina
- Language:Chinese
-
Abstract:
AIM To observe the clinical effects of Gushen Antai Pills (Polygoni multiflori Radix,Rehmanniae Radix,Cistanches Herba,etc.) combined with low-molecular-weight heparin (LMWH) in treating women with recurrent spontaneous abortion (RSA) due to coagulation disorder (prethrombotic state,PTS).METHODS One hundred and twenty-six cases of RSA patients in PTS were randomly assigned to observation group and control group for the treatment of either LMWH combined with Gushen Antai Pills or LMWH.The trial went on during the first twenty weeks of pregnancy.Investigations on total treatment efficiency,coagulation-fibrinolysis indicator levels before and after treatment were conducted,and results of follow-ups were compared as well.RESULTS The total effective rate of 73.0％ in the control group and 87.3％ in the observation group displayed a significant difference (P ＜ 0.05).Although the levels of fibrinogen (FIB),D-dimer (D-D) and plasminogen activator inhibitorl (PAIl) were significantly improved (P ＜ 0.05) after the treatment,the observation group was found to be significantly better in performance than the control group (P ＜ 0.05).The live birth rate of 69.8％ in the control group and 85.7％ in the observation group also showed to be a significant difference (P ＜ 0.05).CONCLUSION Gushen Antai Pills combined with LMWH can improve the thrombotic state and bring forth a higher live birth rate in patients with RSA.
