The regulatory role of cerebellar degeneration-related protein 1 antisense
10.3760/cma.j.issn.1673-4904.2018.01.023
- VernacularTitle:小脑变性相关蛋白1反义转录物的研究进展
- Author:
Wangyang ZHENG
1
;
Zhenglong LI
;
Jinglin LI
;
Xinheng LI
;
Zhidong WANG
;
Yunfu CUI
;
Xingming JIANG
Author Information
1. 150086,哈尔滨医科大学附属第二医院胆胰外科
- Keywords:
Tumor markers;
biological;
Review;
Cerebellar degeneration-related protein 1 antisense
- From:
Chinese Journal of Postgraduates of Medicine
2018;41(1):82-85
- CountryChina
- Language:Chinese
-
Abstract:
Circular RNA is a kind of single-stranded RNA ring without 5'capping and 3'polyadenylation.As a new member of non-coding RNA, circular RNA is evolutionally conserved, relatively stable,highly specific and enormously abundant.Instead of liner RNA,circular RNA became the research hotspot.So far,cerebellar degeneration-related protein 1 antisense(CDR1as)is a molecule that has garnered intense research.CDR1as harbors 74 conventional miRNA-7 binding sites.Expression of CDR1as efficiently tethers micro RNA-7, resulting in reduced micro RNA-7 activity and increased levels of micro RNA-7 targeted transcripts consistent with the micro RNA sponge and competing endogenous RNA(ceRNA)hypothesis.Moreover,CDR1as can restore micro RNA-7 and release it at right time.CDR1as can be stabilized in the exosomes.And its level has correlation with many clinical characteristics.
