Value of Ki-67 and P53 in the diagnosis of three negative breast cancer
10.3969/j.issn.1009-9905.2017.09.007
- VernacularTitle:Ki-67和P53在三阴性乳腺癌诊断中的应用价值
- Author:
Qiang YU
1
;
jun Shi PENG
;
Jing LI
;
Yong ZHOU
;
xiong Xian QIN
;
Min TUO
Author Information
1. 湖北恩施州中心医院乳腺外科 湖北恩施445000
- Keywords:
Breast cancer subtype;
Ki-67;
P53;
Expression
- From:
Chinese Journal of Current Advances in General Surgery
2017;20(9):696-699
- CountryChina
- Language:Chinese
-
Abstract:
Objective:Expression of Ki-67 and p53 in triple-negative breast cancer(TBNC) and its clinical value.Methods:We selected 107 patients with breast cancer from February 2008 to December 2015 were selected as the study subjects,the expression of ER,PR and c-erbB-2 was negative in TNBC group (n=67),and one of them was NTNBC (n=40).To compare the positive rates of Ki-67 and P53 expression in TBNC and NTBNC groups.To analyze the relationship between the positive rate of Ki-67 and P53 expression in TBNC group and clinicopathological features.To analyze the correlation between Ki-67 and P53 expression in TBNC group.Results:The positive rate of Ki-67 expression in TNBC group(71.64％) was higher than that in NTNBC group(27.50％).The positive rate of P53 expression in TNBC group (65.67％) was higher than that in NTNBC group(32.50％),The difference was statistically significant (P＜0.05);The positive rate of Ki-67 and P53 expression in TNM stage Ⅲ +Ⅳ patients was higher than that in patients without lymph node metastasis and stage Ⅰ + Ⅱ,the difference was statistically significant (P＜0.05).The expression of Ki-67 was positively correlated with P53 expression by Spearman rank correlation analysis(rs=0.312,P=0.010).Conclusions:The expression of Ki-67 and P53 in TBNC patients was higher than that in NTNBC patients,and correlated with lymph node metastasis and TNM staging,which could be used as a clinical index to evaluate the occurrence and development of subtype breast cancer.
