Gender-related differences in patients with upper tract urothelial carcinoma: a single-center experience
10.3760/cma.j.issn.1000-6702.2017.12.005
- VernacularTitle:上尿路尿路上皮癌患者性别差异与预后分析:单中心942例报告
- Author:
Wenlong ZHONG
1
;
Gengyan XIONG
;
Lei ZHANG
;
Dong FANG
;
Xuesong LI
;
Liqun ZHOU
Author Information
1. 100034,北京大学第一医院泌尿外科北京大学泌尿外科研究所国家泌尿男性生殖系肿瘤研究中心
- Keywords:
Upper tract urothelial carcinoma(UTUC);
Gender;
Prognosis;
Aristolochic acid
- From:
Chinese Journal of Urology
2017;38(12):901-904
- CountryChina
- Language:Chinese
-
Abstract:
Objective To assess the gender-related differences of upper tract urothelial carcinoma and analyze the causes of the gender-related differences.Methods We retrospectively studied 942 patients underwent radical nephroureterectomy for upper tract urothelial carcinoma between January 2000 and December 2014 in our hospital.The mean age of the entire cohort was 64.5 years,with 424 males (45.0％)and518 females (55.0％).Compared with male patients,female patients tended to had a history of aristolochic acids exposure (5.2％ vs.11.1％,P =0.001),infrequent smoking (29.7％ vs.5.2％,P ＜0.001) and showed poorer renal function (P =0.023).We reviewed clinicopathologic data from these patients and used univariate analysis to determine the gender-related differences.The Kaplan-Meier method was adopted to investigate the gender differences of cancer specific survival,bladder recurrence-free survival and contralateral upper tract recurrence-free survival of patients.Results When compared with males,females were less likely to have high-stage disease (33.7％ vs.24.9％,P =0.003).The mean follow-up for the entire cohort was 70.2 months (4-193 months).The cancer specific survival rate (x2 =14.116,P ＜0.001)and the contralateral upper urinary tract recurrence rate(x2 =7.362,P =0.007)in females were both higher than those in males.The 5-year cancer specific survival rates were 72.0％ in the males and 83.5％ in females,respectively.In addition,the 5-year contralateral UTUC-free survival rates were 98.6％ in the males and 92.9％ in females.Conclusions Female patients in our cohort were more common and they were more likely to be exposed to aristolochic acids.Females were less likely to have high-stage disease but had significantly worse contralateral upper tract recurrence-free survival.
