Research advances in molecular biological mechanisms of neuroblastoma
10.3760/cma.j.issn.2095-428X.2017.23.023
- VernacularTitle:神经母细胞瘤相关分子生物学机制研究进展
- Author:
Shen YANG
1
;
Huanmin WANG
Author Information
1. 100045 北京,国家儿童医学中心,首都医科大学附属北京儿童医院肿瘤外科
- Keywords:
Neuroblastoma;
Molecular biological mechanisms;
Targeted therapy
- From:
Chinese Journal of Applied Clinical Pediatrics
2017;32(23):1836-1840
- CountryChina
- Language:Chinese
-
Abstract:
Neuroblastoma(NB)is the most common solid extracranial tumor of children,which is obviously heterogenous in the positions,histopathological features,and biological characteristics. One of the most intractable issues in the current clinical treatment is the poor prognosis in high - risk and advanced stage of NB. In recent years,numerous studies have been conducted on molecular biological mechanisms of NB. Researches demonstrate that tumorigenesis is related to various factors,including chromosome,oncogene,and antioncogene abnormalities;carcinogenesis related genes (involving cell proliferation,apoptosis,angiogenesis,chemoresistance and intracellular signal transduction system)ab-normalities. Some specific information(such as chromosome 1p status,MYCN expression,and DNA ploidy)has become the important basis for judging prognosis and grouping the patients by risks. Meanwhile,there are still many discovered NB - related molecular biological mechanisms which are not yet included in the risk stratification system. Further development of targeted drugs for those molecules may be of great significance in increasing the survival rate of patients and improving the prognosis.
