Association and its forensic significance between HTR1A gene and the corresponding mental illness

VernacularTitle:HTR1A基因与相应精神疾病的关联及法医学意义
Author: Xue ZHOU ¹ ; Chunli DING ; Baojie WANG ; Mei DING ; Hao PANG
Author Information

1. 舟山市公安局刑事科学技术研究所
Keywords: forensic genetics; serotonin receptors; single nucleotide polymorphisms
From: Chinese Journal of Forensic Medicine 2017;32(6):596-598,602
CountryChina
Language:Chinese
Abstract: HTR1A is a kind of receptor subtypes to express the most 5-HT in the brain of mammalian. Genetic variation in the gene through influencing the expression of receptors or changing the activity of the ligand binding to increase or decrease the function of 5-HT, so it played a key role in the pathogenesis of depression and other mental system diseases. The article reviewed the association between the genetic mutations of HTR1A and the corresponding mental system disease. Research the relationship of HTR1A gene and mood changes such as depression, panic, impulsive personality and its significance in forensic judicial authentication. To explore the causes of criminal mode from the perspective of gene - psychology - social model.