The research progress of the role of NUP155 in atrial fibrillation and primary arrhythmic sudden cardiac death
10.13618/j.issn.1001-5728.2017.06.012
- VernacularTitle:NUP155与房颤及原发性心律失常性猝死关系的研究进展
- Author:
Han REN
1
;
Jianding CHENG
;
Erwen HUANG
Author Information
1. 中山大学中山医学院法医学系
- Keywords:
forensic pathology;
NUP155;
atrial fibrillation;
primary arrhythmic sudden cardiac death
- From:
Chinese Journal of Forensic Medicine
2017;32(6):599-602
- CountryChina
- Language:Chinese
-
Abstract:
NUP155 is a kind of important nucleoporins on the nuclear pore complex which plays an important role in the process of mediating macromolecular substances passing in and out of the nucleus. Primary cardiac arrhythmia is one of the important reasons to lead to sudden death, mainly due to the mutations of the gene which codes ion channel on the myocardial cell membrane, so it's also known as "cardiac ion channel disease".NUP155 is the first found non-ion-channel gene that its mutations can lead to primary cardiac arrhythmias and sudden cardiac death. This article mainly focuses on the structure and biological function of NUP155 and its relationship with Primary arrhythmic sudden cardiac death.
