Changes of coagulation factors stored for different lengths of time after fresh frozen plasma melting

VernacularTitle:新鲜冰冻血浆融化后不同放置时间凝血因子变化的研究
Author: hong Zheng ZHU ¹ ; Jing CHANG ; zhong Long FAN ; ying Yu HE ; juan Li CHEN
Author Information

1. 解放军422医院输血科
Keywords: fresh frozen plasma; thawing; coagulation factor; activity
From: Military Medical Sciences 2017;41(9):739-741
CountryChina
Language:Chinese
Abstract: Objective To study the changes in coagulation factors stored for different lengths of time after fresh frozen plasma(FFP)thawing.Methods Thirty-two samples of thawed FFP were detected by an automated coagulation analyzer SYSMEX CA-1500 to observe the changes in coagulation function and coagulation factors stored for different lengths of time at 4℃.Results Activated partial thromboplastin time (APTT) was significantly prolonged 12 hours after thawing.However, no significant changes were observed in prothrombin time (PT), thrombin time (TT) or fibrinogen (FIB).Coagulation factors showed varying degrees of attenuation in 24 hours.FⅤ, FⅦ and FⅧ were attenuated significantly in 6 hours by 17.2%, 9.47% and 12.5%, respectively.FⅨ began to attenuate in 12 hours and reached, the lowest rate of 21.1%, while FⅧ had the highest attenuation rate (52.0%) and showed the lowest stability.Conclusion The activity of coagulation factors is decreased with time after FFP thawing ,so it should be transfused as soon as possible to ensure the curative effect and clinical application.