Neonatal necrotizing enterocolitis:advance on mechanism of small-molecule drugs
10.3760/cma.j.issn.1673-4912.2017.12.014
- VernacularTitle:新生儿坏死性小肠结肠炎小分子药物作用机制的研究进展
- Author:
Liping CHEN
1
;
Zhibao LYU
Author Information
1. 200040,上海交通大学附属儿童医院 上海市儿童医院普外科
- Keywords:
Infant;
newbown;
Necrotizing enterocolitis;
Small-molecule drugs
- From:
Chinese Pediatric Emergency Medicine
2017;24(12):934-938
- CountryChina
- Language:Chinese
-
Abstract:
Necrotizing enterocolitis(NEC) is the most common disease of gastrointestinal tract in neonate,and is an important cause of neonatal death,especially in premature. Its pathogenesis has not be clear and tends to be multifactorial,leading to the lack of effective prevention and treatment strategies. With the de-velopment of neonatal intensive care unit and the gradually improvement of the nursing level,the diagnostic detection rate of NEC has increased significantly. In addition to conventional surgery and conservative treat-ment,the research and development of new drugs targeting at NEC has been carried out in-depth,including octreotide,erythropoietin,amino acid and all trans retinoic acid. Through the analysis and summary of the mechanism and clinical application of these small-molecule drugs in the treatment of NEC,this review aimed at retrospecting the research progress of NEC drug treatment in recent years to provide relevant background knowledge for clinical prevention,treatment and drug research and development of NEC.
