Genome association studies of Male's height in the Northern Han Chinese
10.13618/j.issn.1001-5728.2017.06.005
- VernacularTitle:北方汉族男性人群身高特征的遗传学研究
- Author:
Yanan SUN
1
;
Wenting ZHAO
;
Li JIANG
;
Jing LIU
;
Xin MA
;
Xingjian GAO
;
Fan LIU
;
Jian YE
;
Caixia LI
Author Information
1. 公安部物证鉴定中心 北京市现场物证检验工程技术研究中心 现场物证溯源技术国家工程实验室
- Keywords:
forensic antropology;
height;
single nucleotide polymorphism;
Northern Han Chinese
- From:
Chinese Journal of Forensic Medicine
2017;32(6):567-572
- CountryChina
- Language:Chinese
-
Abstract:
Objective In order to study 275 reported height-associated single nucleotide polymorphisms (SNPs) in males of Northern Han Chinese. Methods Genotype information was detected by matrix assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOFMS) in 266 Northern Han Chinese male samples. Using PLINK 1.09 and SPSS 19.0 software, three analysis methods were choosen, which were linear regression analysis, logistic regression analysis (tall ≥177.5cm, short ≤167.5cm), and logistic analysis (tall ≥180cm, short ≤165cm). Results We identified 16 SNPs significantly associated with height in our study group(P<0.05), which were analysised by linear regression analysis and logistic regression analysis. Of these, one had been previously described in East Asian (rs11170624), and six had been reported in European (rs10037512、rs17346452、rs2629046、rs7689420、rs8052560、rs7909670). The result of mean variance analysis suggested that the effect of rs11170624、rs17346452、rs7689420 and rs7909670 on height was consistent with previous study. However, compare with European population, the other three loci showed differential contribution of height variation in Northern Han Chinese. Conclusion Further statistical tests in larger numbers of individuals will be required to identify higher population specificity loci affecting stature of Han Chinese, and to build a height prediction model.
