Role of Kupffer cells in hepatitis B virus infection

VernacularTitle:枯否细胞在乙型肝炎病毒感染过程中的作用
Author: Lele SHI ¹ ; Tao WANG ; Sunzedong GU ; Xiaofei YANG ; Ye ZHANG ; Jianqi LIAN
Author Information

1. 空军军医大学唐都医院感染病科
Keywords: Kupffer cells; Hepatitis B virus; Infection; Immunity
From: Chinese Journal of Clinical Infectious Diseases 2017;10(6):473-477
CountryChina
Language:Chinese
Abstract: Hepatitis B virus(HBV)infection is the main cause of chronic liver diseases in China. The clearance of HBV is important for patients with chronic hepatitis B.Current antiviral therapy includes interferon and nucleotide analogues.The adverse reactions of interferon are common which restrict its application.Nucleotide analogues need long-term maintenance treatment.Kupffer cells (KCs) are the main innate immune cells in the liver.Studies have shown that KCs play an important role in hepatitis B virus infection.It can inhibit virus replication effectively , but may also result in immune dysfunction , causing HBV persistence.Understanding the mechanism related to the role of KCs in hepatitis B virus infection may lead to a new approach of antiviral therapy.