Influences of Chinese herbal compound Qinghuayin on serum IL-10 ,NO , GAS and plasma MTL in animal model of chronic atrophic gastritis in rats
10.7652/jdyxb201801025
- VernacularTitle:中药复方清化饮对慢性萎缩性胃炎大鼠血清IL-10、NO、GAS及血浆MTL的影响
- Author:
han Ming HUANG
1
;
rong Wen WANG
;
Jian HUANG
;
dong Guo ZHONG
;
yu Fu XU
;
han Si LI
;
long Jian LIN
;
Xin WANG
;
ming Xiu LIN
;
Ping HENG-QING
;
LIN HUANG
Author Information
1. 福建中医药大学附属第二人民医院
- Keywords:
Qinghuayin;
chronic atrophic gastritis (CAG);
pathology of gastric mucosa;
serum interleukin-10 (IL-10);
serum nitric oxide (NO);
serum gasmn;
plasma motilin (MTL);
rat
- From:
Journal of Xi'an Jiaotong University(Medical Sciences)
2018;39(1):116-120
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effects of Chinese herbal compound Qinghuayin on the pathological changes of gastric mucosa and interleukin-10 (IL-10) ,nitric oxide (NO) ,gasmn (GAS) and motilin (MTL) in the serum in the animal model of chronic atrophic gastritis (CAG ) in rats .Methods We divided 53 Wistar rats randomly into blank control group (n=8) and CAG model group (n=45) ,and the animal model of CAG in rats was replicated by combination of disease and syndrome .After confirming the sampled rat model was successful built , the other 40 CAG rats in CAG model group were divided into model group ,vitacoenzyme tablet group ,low-dosage TMC group ,medium-dosage TMC group ,and high-dosage TMC group (each group n=8) .With the corresponding drug intervention to different rats for 30 days , the rats were executed . Then their blood was drawn from the abdominal aorta and the gastric tissue was taken to analyze the changes of serum IL-10 ,NO ,GAS and MTL concentrations and gastric mucosa pathology . Results Compared with blank control group , model group had various degrees of gastric mucosa atrophy ; decreased concentrations of serum IL-10 and GAS ; increased NO and MTL ( P<0 .01 ) .Compared with model group,Qinghuayin could improve gastric mucosa pathology in different degrees and increase the concentrations of IL-10 and GAS . Decrease the concentrations of NO and MTL( P<0 .05 or P<0 .01 ) . What's more. The curative effect in high-dosage TMC group was better( P<0. 01 ). Conclusion Chinese herbal compound Qinghuayin can effectively regulate the lopsided expressions of serum IL-10 . NO .GAS and MTL and reverse the pathological and histological changes in the gastric mucosa of CAG rats .
