Effects and mechanisms of mesenteric arterial rings vasodilation induced by protocatechuic aldehyde
10.7652/jdyxb201801008
- VernacularTitle:原儿茶醛对大鼠离体肠系膜上动脉血管环的舒张作用及机制
- Author:
Han ZHANG
1
;
huan Huan LIU
;
Min JIA
;
Yan ZHANG
;
ji Xu SHEN
;
long Yu CHEN
Author Information
1. 西安医学院药学院
- Keywords:
protocatechuic aldehyde (PCA );
arterial ring;
vasodilatation;
potassium channel;
endothelial mechanism inhibitor;
superior mesenteric artery
- From:
Journal of Xi'an Jiaotong University(Medical Sciences)
2018;39(1):31-35,72
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the vasodilating effects of protocatechuic aldehyde (PCA ) on rat superior mesenteric arterial rings as well as its mechanism .Methods The tension of rat superior mesenteric arterial rings was recorded by a sensitive myograph system in vitro . We measured isometric tension changes in preconstricted rat superior mesenteric artery rings induced by potassium chloride (KCl ,60 mmol/L) ,serotomin (5-HT ,10-5 mol/L ) , and phenylephrine (PE , 10-5 mol/L ) after PCA treatment at different concentrations , respectively .We also observed vasodilating effects of PCA on KCl (60 mmol/L ) preconstricted rat superior mesenteric arterial rings after incubation with different inhibitors ,i .e .,L-NAME ,Indo ,ODQ ,4-AP (KV channel blocker) ,TEA (KCa channel blocker) ,BaCl2 (Kir channel blocker) ,and Glib (KATP channel blocker) ,respectively . Results PCA (10-6 -10-3 mol/L ) could relax KCl (60 mmol/L ) and 5-HT (10-5 mol/L ) preconstricted rat superior mesenteric arterial rings in a concentration-dependent manner . Indo of endothelial mechanism inhibitor blocked the vasodilating effect of PCA . 4-AP and BaCl2 of potassium ion channel inhibitors affected the vasodilatation induced by PCA in KCl (60 mmol/L)-preconstricted rat mesenteric artery .Conclusion PCA can relax KCl (60 mmol/L) ,or 5-HT preconstricted rat superior mesenteric arterial rings .This effect is associated with the inhibition of potassium channels and endothelial mechanism .
