Studies on resistance of Schistosoma to praziquantel (ⅩⅥ)Biological characteris- tics of praziquantel-resistant isolates of Schistomoma japonicum in Oncomelania hupensis snails
10.16250/j.32.1374.2017101
- VernacularTitle:血吸虫对吡喹酮抗药性的研究(ⅩⅥ)日本血吸虫吡喹酮抗性株在钉螺体内的生物学特性
- Author:
Ke QIAN
1
,
2
;
江西省南昌市疾病预防控制中心
;
sheng You LIANG
;
Wei WANG
;
li Guo QU
;
jun Hong LI
;
kun Zhen YANG
;
yang Zheng ZHAO
;
tian Yun XING
;
rong Jian DAI
Author Information
1. 国家卫生和计划生育委员会寄生虫病预防与控制技术重点实验室、江苏省寄生虫与媒介控制技术重点实验室、江苏省血吸虫病防治研究所、江南大学公共卫生研究中心 无锡214064
2. 江西省南昌市疾病预防控制中心
- Keywords:
Schistosoma japonicum;
Praziquantel;
Drug resistance;
Oncomelania hupensis;
Biological characteristics
- From:
Chinese Journal of Schistosomiasis Control
2017;29(6):678-682
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the difference of biological characteristics between the praziquantel-resistant and-sus-ceptible isolates of Schistosoma japonicum in intermediate host Oncomelania hupensis snails. Methods Mice were infected with cercariae of praziquantel-resistant and-susceptible isolates of S. japonicum,and the parasite eggs were collected 37 days post-in-fection to hatch miracidium. Then,the snails were infected with the miracidium of each parasite isolate. The snail infection,sur-vival rate of infected snails,prepatent period of cercariae,and the total number of cercariae shed from each infected snail were observed and compared between the praziquantel-resistant and-susceptible isolates of S. japonicum. Results If each snail was exposed to a single miracidium,there were significant differences between the praziquantel-resistant and-susceptible Jiangsu isolates in the snail infection(8.99％vs. 19.74％;χ2=3.948,P=0.047)and the number of cercaria released from a single snail (1460.2 vs. 1039.3;t=2.507,P=0.02),and there were significant differences between the praziquantel-susceptible and-re-sistant Hunan isolates in the snail infection(10.00％vs. 21.52％;χ2=3.980,P=0.046)and the number of cercaria released from a single snail(1319.4 vs. 1003.5;t=2.566,P=0.017). However,there were no significant differences between the pra-ziquantel-resistant and-susceptible isolates of S. japonicum in the prepatent period of cercariae and the survival rate of infected snails(P>0.05). Conclusion The praziquantel-resistant isolate of S. japonicum has a higher susceptibility to O. hupensis but less cercaria released from each infected snail than the susceptible isolate.
